Reaction Details Report a problem with these data
Target
Beta-3 adrenergic receptor
Ligand
BDBM50106802
Substrate
n/a
Meas. Tech.
ChEBML_39052
Ki
133±n/a nM
Citation
Washburn, WN; Sher, PM; Poss, KM; Girotra, RN; McCann, PJ; Gavai, AV; Mikkilineni, AB; Mathur, A; Cheng, P; Dejneka, TC; Sun, CQ; Wang, TC; Harper, TW; Russell, AD; Slusarchyk, DA; Skwish, S; Allen, GT; Hillyer, DE; Frohlich, BH; Abboa-Offei, BE; Cap, M; Waldron, TL; George, RJ; Tesfamariam, B; Ciosek, CP; Ryono, D; Young, DA; Dickinson, KE; Seymour, AA; Arbeeny, CM; Gregg, RE Beta 3 agonists. Part 1: evolution from inception to BMS-194449. Bioorg Med Chem Lett 11:3035-9 (2001) [PubMed] Article
More Info.:
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Human
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
Inhibitor
Name:
BDBM50106802
Synonyms:
CHEMBL319257 | N-(5-{2-[1-(3,4-Dimethyl-phenyl)-2-phenyl-ethylamino]-1-hydroxy-ethyl}-2-hydroxy-phenyl)-methanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C25H30N2O4S
Mol. Mass.:
454.582
SMILES:
Cc1ccc(cc1C)C(Cc1ccccc1)NCC(O)c1ccc(O)c(NS(C)(=O)=O)c1