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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50035097
Substrate
n/a
Meas. Tech.
ChEMBL_202051 (CHEMBL809524)
IC50
12±n/a nM
Citation
 Moltzen, EK; Perregaard, J; Meier, E Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 2. Spiro-joined benzofuran, isobenzofuran, and benzopyran piperidines. J Med Chem 38:2009-17 (1995) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
Rat
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50035097
Synonyms:
1''-benzyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-piperidine](L-687,384) | 1''-benzyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-piperidine]; HCl | 1''-benzylspiro[1,2,3,4-tetrahydronaphthalene-1,4''-(hexahydropyridine)] | 1'-benzylspiro[1,2,3,4-tetrahydronaphthalene-1,4'-(hexahydropyridine)](L-687,384) | CHEMBL1256916 | CHEMBL303336 | L-687384
Type:
Small organic molecule
Emp. Form.:
C21H25N
Mol. Mass.:
291.4299
SMILES:
C(N1CCC2(CCCc3ccccc23)CC1)c1ccccc1
Structure:
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