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Target
Histamine H4 receptor
Ligand
BDBM50133018
Substrate
n/a
Meas. Tech.
ChEMBL_87092 (CHEMBL700770)
Ki
5±n/a nM
Citation
 Jablonowski, JA; Grice, CA; Chai, W; Dvorak, CA; Venable, JD; Kwok, AK; Ly, KS; Wei, J; Baker, SM; Desai, PJ; Jiang, W; Wilson, SJ; Thurmond, RL; Karlsson, L; Edwards, JP; Lovenberg, TW; Carruthers, NI The first potent and selective non-imidazole human histamine H4 receptor antagonists. J Med Chem 46:3957-60 (2003) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Human
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50133018
Synonyms:
(4,5-Dichloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone | (4,5-dichloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone | CHEMBL129436
Type:
Small organic molecule
Emp. Form.:
C14H15Cl2N3O
Mol. Mass.:
312.194
SMILES:
CN1CCN(CC1)C(=O)c1cc2c(Cl)c(Cl)ccc2[nH]1
Structure:
Search PDB for entries with ligand similarity: