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Target
Thymidylate kinase
Ligand
BDBM50156576
Substrate
n/a
Meas. Tech.
ChEMBL_429556 (CHEMBL919554)
Ki
80000±n/a nM
Citation
 Vanheusden, V; Munier-Lehmann, H; Froeyen, M; Busson, R; Rozenski, J; Herdewijn, P; Van Calenbergh, S Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase. J Med Chem 47:6187-94 (2004) [PubMed]  Article 
Target
Name:
Thymidylate kinase
Synonyms:
KTHY_MYCTU | TMPK | Thymidine monophosphate kinase | dTMP kinase | tmk
Type:
PROTEIN
Mol. Mass.:
22636.29
Organism:
Mycobacterium tuberculosis
Description:
ChEMBL_208218
Residue:
214
Sequence:
MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLASSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWVQRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYAELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
  
Inhibitor
Name:
BDBM50156576
Synonyms:
1-(3-azidomethyl-2,5-difluoro-2,3,5-trideoxy-beta-D-ribofuranosyl)thymine | CHEMBL222970
Type:
Small organic molecule
Emp. Form.:
C11H13F2N5O3
Mol. Mass.:
301.2494
SMILES:
Cc1cn([C@@H]2O[C@H](CF)[C@@H](CN=[N+]=[N-])[C@H]2F)c(=O)[nH]c1=O |r|
Structure:
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