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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50241345
Substrate
n/a
Meas. Tech.
ChEMBL_533382 (CHEMBL980608)
IC50
1280±n/a nM
Citation
 Yoo, NH; Jang, DS; Yoo, JL; Lee, YM; Kim, YS; Cho, JH; Kim, JS Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activity. J Nat Prod 71:713-5 (2008) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50241345
Synonyms:
Apigenin 7-O-β-D-glucuronide (9) | CHEMBL254213 | apigenin-7-O-beta-D-glucuronide | apigenin-7-O-betaD-glucuronic acid
Type:
Small organic molecule
Emp. Form.:
C21H18O11
Mol. Mass.:
446.361
SMILES:
O[C@H]1[C@H](Oc2cc(O)c3c(c2)oc(cc3=O)-c2ccc(O)cc2)O[C@@H]([C@@H](O)[C@@H]1O)C(O)=O |r|
Structure:
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