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Target
Glucagon-like peptide 1 receptor
Ligand
BDBM50324716
Substrate
n/a
Meas. Tech.
ChEMBL_651180 (CHEMBL1227945)
EC50
0.075±n/a nM
Citation
 Day, JW; Ottaway, N; Patterson, JT; Gelfanov, V; Smiley, D; Gidda, J; Findeisen, H; Bruemmer, D; Drucker, DJ; Chaudhary, N; Holland, J; Hembree, J; Abplanalp, W; Grant, E; Ruehl, J; Wilson, H; Kirchner, H; Lockie, SH; Hofmann, S; Woods, SC; Nogueiras, R; Pfluger, PT; Perez-Tilve, D; DiMarchi, R; Tschöp, MH A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nat Chem Biol 5:749-57 (2009) [PubMed]  Article 
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1)
Type:
Enzyme
Mol. Mass.:
53035.78
Organism:
Homo sapiens (Human)
Description:
P43220
Residue:
463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
  
Inhibitor
Name:
BDBM50324716
Synonyms:
CHEMBL1222090
Type:
Small organic molecule
Emp. Form.:
C157H233N43O49S
Mol. Mass.:
3538.854
SMILES:
CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:181.194,171.178,151.164,136.145,116.123,99.107,77.87,63.71,43.53,30.37,8.12,235.241,209.217,wD:192.198,223.231,177.182,226.234,163.172,145.151,124.136,108.115,88.98,72.75,54.62,39.41,16.28,4.4,243.249,244.252,213.218,200.211,(49.67,-5.25,;48.36,-4.46,;48.36,-2.87,;47.06,-2.08,;47.06,-.49,;45.75,.31,;44.45,-.48,;44.45,-2.07,;43.13,.31,;43.13,1.9,;44.45,2.7,;44.45,4.28,;45.75,1.9,;41.82,-.48,;40.51,.31,;40.51,1.9,;39.21,-.48,;39.21,-2.07,;40.51,-2.86,;41.89,-2.22,;42.91,-3.4,;42.14,-4.78,;42.61,-6.29,;41.59,-7.47,;40.12,-7.13,;39.65,-5.62,;40.67,-4.44,;37.9,.32,;36.59,-.47,;36.59,-2.07,;35.28,.32,;35.28,1.91,;36.59,2.71,;36.59,4.29,;35.29,5.08,;37.91,5.08,;33.97,-.47,;32.67,.32,;32.67,1.91,;31.36,-.47,;30.05,.33,;28.74,-.47,;28.74,-2.06,;27.42,.33,;27.42,1.92,;28.74,2.72,;30.09,1.98,;31.41,2.78,;31.37,4.32,;30.01,5.06,;28.7,4.25,;26.13,-.46,;24.8,.33,;24.8,1.92,;23.51,-.46,;23.51,-2.05,;24.8,-2.84,;24.77,-4.38,;23.41,-5.12,;26.08,-5.19,;22.2,.34,;20.89,-.46,;20.89,-2.05,;19.58,.34,;19.58,1.92,;20.89,2.73,;20.89,4.31,;22.23,5.08,;22.23,6.62,;18.27,-.45,;16.96,.34,;16.96,1.93,;15.65,-.45,;15.65,-2.04,;14.36,.35,;13.04,-.44,;13.04,-2.04,;11.73,.35,;11.73,1.93,;13.04,2.74,;13.04,4.32,;14.36,5.11,;14.36,6.71,;13.04,7.49,;15.66,7.5,;10.43,-.44,;9.11,.35,;9.11,1.94,;7.8,-.43,;7.8,-2.03,;9.11,-2.82,;9.11,-4.41,;10.44,-5.19,;10.44,-6.73,;11.78,-7.5,;9.11,-7.5,;6.49,.36,;5.2,-.42,;5.2,-2.03,;3.88,.37,;3.88,1.95,;5.22,2.72,;5.22,4.26,;3.88,5.03,;6.55,5.03,;2.58,-.42,;1.26,.37,;1.26,1.95,;-.05,-.42,;-.05,-2.01,;1.26,-2.81,;2.56,-2.01,;1.26,-4.4,;-1.36,.37,;-2.66,-.41,;-2.66,-2.01,;-3.97,.37,;-3.97,1.96,;-2.66,2.76,;-2.66,4.35,;-1.35,1.96,;-5.28,-.41,;-6.59,.38,;-6.59,1.96,;-7.89,-.41,;-7.89,-2.01,;-6.59,-2.8,;-5.28,-2.01,;-3.98,-2.8,;-3.98,-4.39,;-2.66,-5.19,;-5.28,-5.18,;-6.59,-4.39,;-9.22,.38,;-10.52,-.4,;-10.52,-2,;-11.82,.38,;-11.82,1.97,;-10.52,2.77,;-10.52,4.36,;-9.21,5.16,;-9.21,6.74,;-13.13,-.4,;-14.43,.39,;-14.43,1.97,;-15.76,-.4,;-15.76,-2,;-14.43,-2.79,;-17.07,.39,;-18.37,-.39,;-18.37,-1.99,;-19.69,.39,;-19.69,1.98,;-18.37,2.78,;-17.06,1.97,;-15.76,2.77,;-15.75,4.36,;-14.43,5.16,;-17.06,5.17,;-18.37,4.37,;-20.98,-.39,;-22.29,.4,;-22.29,1.98,;-23.61,-.39,;-23.61,-1.98,;-22.29,-2.78,;-20.99,-1.98,;-22.29,-4.37,;-24.91,.4,;-26.23,-.39,;-26.23,-1.98,;-27.53,.4,;-27.53,1.99,;-26.23,2.79,;-28.84,-.38,;-30.16,.41,;-30.16,1.99,;-31.44,-.38,;-32.78,.41,;-34.07,-.38,;-34.07,-1.97,;-35.38,.41,;-35.38,2,;-34.07,2.8,;-32.77,1.99,;-31.45,2.79,;-31.45,4.38,;-32.77,5.18,;-34.07,4.38,;-36.69,-.37,;-37.99,.41,;-37.99,2,;-39.32,-.37,;-40.62,.42,;-41.92,-.37,;-41.92,-1.96,;-43.23,.42,;-44.54,-.36,;-45.85,.42,;-45.85,2.01,;-47.15,-.36,;-47.15,-1.95,;-45.85,-2.75,;-45.85,-4.34,;-47.16,-5.14,;-44.55,-5.14,;-48.46,.42,;-49.77,-.36,;-49.77,-1.95,;-51.09,.42,;-51.09,2.01,;-49.77,2.82,;-52.4,-.36,;-53.73,.42,;-53.73,1.94,;-55.05,2.7,;-56.3,1.84,;-57.53,2.76,;-57.03,4.21,;-55.49,4.18,;-55.06,-.35,;-56.38,.42,;-55.06,-1.89,;-39.32,-1.96,;-40.62,-2.76,;-37.99,-2.76,;-31.44,-1.97,;-32.78,-2.77,;-30.16,-2.77,;31.36,-2.06,;32.67,-2.85,;30.05,-2.85,;48.36,.31,;48.36,1.89,;49.68,-.49,;50.98,.3,;50.98,1.89,;52.29,2.69,;53.6,1.89,;52.29,4.28,;52.29,-.49,;52.29,-2.08,;53.6,.3,;54.91,-.5,;54.91,-2.09,;53.6,-2.88,;56.22,-2.88,;56.22,.3,;57.53,-.5,;56.22,1.88,)|
Structure:
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