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Target
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Ligand
BDBM50397054
Substrate
n/a
Meas. Tech.
ChEMBL_863458 (CHEMBL2174655)
IC50
63±n/a nM
Citation
 Banerjee, A; Patil, S; Pawar, MY; Gullapalli, S; Gupta, PK; Gandhi, MN; Bhateja, DK; Bajpai, M; Sangana, RR; Gudi, GS; Khairatkar-Joshi, N; Gharat, LA Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson's disease model. Bioorg Med Chem Lett 22:6286-91 (2012) [PubMed]  Article 
Target
Name:
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Synonyms:
P2A | PDE7A_MOUSE | Pde7a
Type:
PROTEIN
Mol. Mass.:
52494.24
Organism:
Mus musculus
Description:
ChEMBL_863458
Residue:
456
Sequence:
MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFETERRGSHPYIDFRIFHSQSDIEASVSARNIRRLLSFQRYLRSSRVFRGATVCSSLDILDEDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMVKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNSSVLENHHWRSAVGLLRESGLFSHLPLESRQEMEAQIGALILATDISRQNEYLSLFRSHLDKGDLHLDDGRHRHLVLQMALKCADICNPCRNWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRQTESIANIQIGFMTYLVEPLFTEWARFSDTRLSQTMLGHVGLNKASWKGLQRQQPSSEDANAAFELNSQLLTQENRLS
  
Inhibitor
Name:
BDBM50397054
Synonyms:
CHEMBL2171421
Type:
Small organic molecule
Emp. Form.:
C19H23N5O2
Mol. Mass.:
353.4182
SMILES:
COc1cc(N)ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1
Structure:
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