Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM50422983
Substrate
n/a
Meas. Tech.
ChEMBL_438068 (CHEMBL906324)
IC50
2.0±n/a nM
Citation
 Hall, A; Brown, SH; Chessell, IP; Chowdhury, A; Clayton, NM; Coleman, T; Giblin, GM; Hammond, B; Healy, MP; Johnson, MR; Metcalf, A; Michel, AD; Naylor, A; Novelli, R; Spalding, DJ; Sweeting, J; Winyard, L 1,5-Biaryl pyrrole derivatives as EP1 receptor antagonists. Structure-activity relationships of 6-substituted and 5,6-disubstituted benzoic acid derivatives. Bioorg Med Chem Lett 17:916-20 (2007) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
PE2R1_HUMAN | PGE receptor, EP1 subtype | PTGER1 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP1 subtype | Prostaglandin E2 receptor EP1 subtype (EP1) | Prostanoid EP1 receptor
Type:
Enzyme
Mol. Mass.:
41834.57
Organism:
Homo sapiens (Human)
Description:
P34995
Residue:
402
Sequence:
MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
  
Inhibitor
Name:
BDBM50422983
Synonyms:
CHEMBL395488
Type:
Small organic molecule
Emp. Form.:
C25H18BrF2NO4
Mol. Mass.:
514.316
SMILES:
Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1ccc(O)c(c1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: