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Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM50197898
Substrate
n/a
Meas. Tech.
ChEMBL_468124 (CHEMBL934144)
IC50
2.5±n/a nM
Citation
 Hall, A; Bit, RA; Brown, SH; Chowdhury, A; Giblin, GM; Hurst, DN; Kilford, IR; Lewell, X; Naylor, A; Scoccitti, T Novel methylene-linked heterocyclic EP1 receptor antagonists. Bioorg Med Chem Lett 18:1592-7 (2008) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
PE2R1_HUMAN | PGE receptor, EP1 subtype | PTGER1 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP1 subtype | Prostaglandin E2 receptor EP1 subtype (EP1) | Prostanoid EP1 receptor
Type:
Enzyme
Mol. Mass.:
41834.57
Organism:
Human
Description:
P34995
Residue:
402
Sequence:
MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
  
Inhibitor
Name:
BDBM50197898
Synonyms:
6-(2-(2-(2,4-difluorobenzyloxy)-5-chlorophenyl)cyclopent-1-enyl)picolinic acid | 6-(2-(5-chloro-2-(2,4-difluorobenzyloxy)phenyl)cyclopent-1-enyl)picolinic acid | CHEMBL234940
Type:
Small organic molecule
Emp. Form.:
C24H18ClF2NO3
Mol. Mass.:
441.854
SMILES:
OC(=O)c1cccc(n1)C1=C(CCC1)c1cc(Cl)ccc1OCc1ccc(F)cc1F |t:10|
Structure:
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