Reaction Details Report a problem with these data
Target
Inosine-5'-monophosphate dehydrogenase
Ligand
BDBM81424
Substrate
n/a
Meas. Tech.
ChEMBL_934904 (CHEMBL2319790)
IC50
1000±n/a nM
Citation
 Johnson, CR; Gorla, SK; Kavitha, M; Zhang, M; Liu, X; Striepen, B; Mead, JR; Cuny, GD; Hedstrom, L Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum. Bioorg Med Chem Lett 23:1004-7 (2013) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase
Synonyms:
Cgd6_20 protein | IMDH_CRYPV | Inosine-5'-monophosphate dehydrogenase, probable | Inosine-5-monophosphate dehydrogenase (IMPDH)
Type:
Protein
Mol. Mass.:
43076.80
Organism:
Cryptosporidium parvum
Description:
Q8T6T2
Residue:
400
Sequence:
MGTKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSAMDTVTEHLMAVGMARLGGIGIIHKNMDMESQVNEVLKVKNWISNLEKNESTPDQNLDKESTDGKDTKSNNNIDAYSNENLDNKGRLRVGAAIGVNEIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIKSKMNIDVIVGNVVTEEATKELIENGADGIKVGIGPGSICTTRIVAGVGVPQITAIEKCSSVASKFGIPIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELIGDTVYKYYRGMGSVGAMKSGSGDRYFQEKRPENKMVPEGIEGRVKYKGEMEGVVYQLVGGLRSCMGYLGSASIEELWKKSSYVEITTSGLRESHVHDVEIVKEVMNYSK
  
Inhibitor
Name:
BDBM81424
Synonyms:
N-(4-methoxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide, Compound D
Type:
Small organic molecule
Emp. Form.:
C18H17N3O3
Mol. Mass.:
323.3459
SMILES:
COc1ccc(NC(=O)Cc2nn(C)c(=O)c3ccccc23)cc1
Structure:
Search PDB for entries with ligand similarity: