Reaction Details Report a problem with these data
Target
Prostaglandin D2 receptor 2
Ligand
BDBM50442299
Substrate
n/a
Meas. Tech.
ChEMBL_993363 (CHEMBL2444558)
Ki
10±n/a nM
Citation
Sandham, DA; Arnold, N; Aschauer, H; Bala, K; Barker, L; Brown, L; Brown, Z; Budd, D; Cox, B; Docx, C; Dubois, G; Duggan, N; England, K; Everatt, B; Furegati, M; Hall, E; Kalthoff, F; King, A; Leblanc, CJ; Manini, J; Meingassner, J; Profit, R; Schmidt, A; Simmons, J; Sohal, B; Stringer, R; Thomas, M; Turner, KL; Walker, C; Watson, SJ; Westwick, J; Willis, J; Williams, G; Wilson, C Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases. Bioorg Med Chem 21:6582-91 (2013) [PubMed] Article
More Info.:
Target
Name:
Prostaglandin D2 receptor 2
Synonyms:
CD294 antigen | Crth2 | G protein-coupled receptor 44 | Gpr44 | PD2R2_MOUSE | Ptgdr2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42975.89
Organism:
Mus musculus (mouse)
Description:
Human embryonic kidney (HEK) 293(EBNA) cells were transfected with mouse CRTH2.
Residue:
382
Sequence:
MANVTLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWNPGPDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVLVEDSDQSGGLRNRRRRASSTATPASTLLLADRIPQLRPTRLIGWMRRGSAEVPQRV