Reaction Details Report a problem with these data
Target
Perforin-1
Ligand
BDBM50445283
Substrate
n/a
Meas. Tech.
ChEMBL_1285138 (CHEMBL3106784)
IC50
1180±n/a nM
Citation
Spicer, JA; Lena, G; Lyons, DM; Huttunen, KM; Miller, CK; O'Connor, PD; Bull, M; Helsby, N; Jamieson, SM; Denny, WA; Ciccone, A; Browne, KA; Lopez, JA; Rudd-Schmidt, J; Voskoboinik, I; Trapani, JA Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin. J Med Chem 56:9542-55 (2014) [PubMed] Article
More Info.:
Target
Name:
Perforin-1
Synonyms:
PERF_HUMAN | PFP | PRF1
Type:
PROTEIN
Mol. Mass.:
61392.32
Organism:
Human
Description:
ChEMBL_1285138
Residue:
555
Sequence:
MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFPVDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARDAARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYSFHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERHSEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREALRRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVTFIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRLQVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQMLLGEPPGNRSGAVW