Target
Glucagon receptor
Ligand
BDBM50007211
Substrate
n/a
Meas. Tech.
ChEMBL_1338729 (CHEMBL3242200)
IC50
500±n/a nM
Citation
 DeMong, DDai, XHwa, JMiller, MLin, SIKang, LStamford, AGreenlee, WYu, WWong, MLavey, BKozlowski, JZhou, GYang, DYPatel, BSoriano, AZhai, YSondey, CZhang, HLachowicz, JGrotz, DCox, KMorrison, RAndreani, TCao, YLiang, MMeng, TMcNamara, PWong, JBradley, PFeng, KIBelani, JChen, PDai, PGauuan, JLin, PZhao, H The discovery of N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): a potent and selective glucagon receptor antagonist. J Med Chem 57:2601-10 (2014) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GL-R | GLR_MOUSE | Gcgr
Type:
PROTEIN
Mol. Mass.:
54941.21
Organism:
Mus musculus
Description:
ChEMBL_1338729
Residue:
485
Sequence:
MPLTQLHCPHLLLLLLVLSCLPEAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQPWRNASQCQLDDEEIEVQKGVAKMYSSQQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAMAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSLATFSERSFFSLYLGIGWGAPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVFLALLINFFIFVHIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFLSSFQGLLVAVLYCFLNKEVQAELMRRWRQWQEGKALQEERLASSHGSHMAPAGPCHGDPCEKLQLMSAGSSSGTGCVPSMETSLASSLPRLADSPT
  
Inhibitor
Name:
BDBM50007211
Synonyms:
CHEMBL3237923
Type:
Small organic molecule
Emp. Form.:
C31H37Cl2N7O2
Mol. Mass.:
610.577
SMILES:
CCC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(Cl)cc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1 |r,wU:12.16,3.2,wD:9.10,c:7,(54.02,-13.47,;55.35,-12.68,;55.33,-11.14,;56.65,-10.36,;56.6,-8.82,;57.81,-7.87,;59.29,-8.29,;57.28,-6.42,;55.73,-6.48,;55.32,-7.96,;54.13,-6.98,;52.69,-7.51,;52.42,-9.02,;53.61,-10.01,;55.06,-9.48,;50.98,-9.56,;49.8,-8.57,;49.54,-10.09,;50.72,-11.07,;58.05,-5.09,;57.29,-3.76,;58.07,-2.43,;57.3,-1.09,;59.61,-2.43,;60.37,-3.78,;61.91,-3.78,;59.6,-5.11,;57.98,-11.14,;57.96,-12.69,;59.28,-13.47,;60.63,-12.72,;60.65,-11.18,;59.32,-10.4,;61.95,-13.51,;61.93,-15.05,;63.29,-12.76,;64.62,-13.54,;65.96,-12.79,;67.35,-13.42,;68.4,-12.29,;67.64,-10.95,;66.13,-11.25,)|
Structure:
Search PDB for entries with ligand similarity: