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Target
Amine oxidase [flavin-containing] A
Ligand
BDBM50023741
Substrate
n/a
Meas. Tech.
ChEMBL_1434487 (CHEMBL3388873)
IC50
21±n/a nM
Citation
 Vianello, P; Botrugno, OA; Cappa, A; Ciossani, G; Dessanti, P; Mai, A; Mattevi, A; Meroni, G; Minucci, S; Thaler, F; Tortorici, M; Trifiró, P; Valente, S; Villa, M; Varasi, M; Mercurio, C Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A. Eur J Med Chem 86:352-63 (2014) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA)
Type:
Protein
Mol. Mass.:
59689.53
Organism:
Homo sapiens (Human)
Description:
P21397
Residue:
527
Sequence:
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
  
Inhibitor
Name:
BDBM50023741
Synonyms:
CHEMBL3330334
Type:
Small organic molecule
Emp. Form.:
C17H20ClN
Mol. Mass.:
273.8
SMILES:
Cl.N[C@]1(CCc2ccccc2)C[C@H]1c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: