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Target
Reduced folate transporter
Ligand
BDBM50027657
Substrate
n/a
Meas. Tech.
ChEMBL_1431343 (CHEMBL3387469)
IC50
>1000±n/a nM
Citation
 Golani, LK; George, C; Zhao, S; Raghavan, S; Orr, S; Wallace, A; Wilson, MR; Hou, Z; Matherly, LH; Gangjee, A Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptorsa andß and the proton-coupled folate transporter. J Med Chem 57:8152-66 (2014) [PubMed]  Article 
Target
Name:
Reduced folate transporter
Synonyms:
FLOT1 | FOLT | Folate transporter 1 | IFC-1 | Intestinal folate carrier | Placental folate transporter | RFC | RFC1 | Reduced folate carrier protein | S19A1_HUMAN | SLC19A1 | Solute carrier family 19 member 1
Type:
PROTEIN
Mol. Mass.:
64885.16
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469594
Residue:
591
Sequence:
MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFTREQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQLMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRVSFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRGRCETSASELERMNPGPGGKLGHALRVACGDSVLARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTNSARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPSSIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSDVRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKAAQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPVTTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ
  
Inhibitor
Name:
BDBM50027657
Synonyms:
CHEMBL3335607
Type:
Small organic molecule
Emp. Form.:
C19H23N5O4S
Mol. Mass.:
417.482
SMILES:
CCC[C@H](NC(=O)c1ccc(CCCc2cc3c(nc(N)[nH]c3=O)[nH]2)s1)C(O)=O |r|
Structure:
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