Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50217241
Substrate
n/a
Meas. Tech.
ChEMBL_83499 (CHEMBL694068)
Ki
2.1±n/a nM
Citation
 Tozer, MJ; Buck, IM; Cooke, T; Kalindjian, SB; McDonald, IM; Pether, MJ; Steel, KI 4-Chlorobenzyl sulfonamide and sulfamide derivatives of histamine homologues: the design of potent histamine H3 receptor antagonists. Bioorg Med Chem Lett 9:3103-8 (1999) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HISTAMINE H3 | HRH3 | HRH3_CAVPO | Histamine H3 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48753.61
Organism:
Guinea pig
Description:
HISTAMINE H3 HRH3 GUINEA PIG::Q9JI35
Residue:
445
Sequence:
MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGAREAGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50217241
Synonyms:
CHEMBL104366
Type:
Small organic molecule
Emp. Form.:
C14H19IN4O2S
Mol. Mass.:
434.296
SMILES:
Ic1ccc(CNS(=O)(=O)NCCCCc2c[nH]cn2)cc1
Structure:
Search PDB for entries with ligand similarity: