Reaction Details
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Mitogen-activated protein kinase 1
Ligand
BDBM199781
Substrate
n/a
Meas. Tech.
IMAP-FP Assay
IC50
0.4±n/a nM
Citation
Wilson, KJ; Witter, DJ; Daniels, MH; Angeles, AR; Siliphaivanh, P; Sloman, D; O'Boyle, B; Falcone, D; White, C; Ferguson, R; Zhou, W; Lipford, K; Mansoor, UF; Fevrier, S; Huang, X; Kurukulasuriya, R; Richard, JE; Tang, S; Boyce, C; Kozlowski, J; Bakshi, RK; Karunakaran, GB Compounds that are ERK inhibitors US Patent US9226922 Publication Date 1/5/2016 More Info.:
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Human
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
Inhibitor
Name:
BDBM199781
Synonyms:
US9226922, 417
Type:
Small organic molecule
Emp. Form.:
C20H23F2N5O4
Mol. Mass.:
435.4245
SMILES:
CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCOC(F)F)c2cn1)c1ccccc1 |r|
Structure:
