Target
COP9 signalosome complex subunit 5
Ligand
BDBM224012
Substrate
n/a
Meas. Tech.
In Vitro Csn5 Activity Assay
pH
7.5±0
IC50
3.0e+4±n/a nM
Citation
 Li, JYakushi, TParlati, FMackinnon, ALPerez, CMa, YCarter, KPColayco, SMagnuson, GBrown, BNguyen, KVasile, SSuyama, ESmith, LHSergienko, EPinkerton, ABChung, TDYPalmer, AEPass, IHess, SCohen, SMDeshaies, RJ Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol 13:486-493 (2017) [PubMed]  Article 
Target
Name:
COP9 signalosome complex subunit 5
Synonyms:
COP9 signalosome complex subunit 5 (Csn5) | COPS5 | CSN5 | CSN5_HUMAN | JAB1
Type:
Protein
Mol. Mass.:
37578.39
Organism:
Homo sapiens (Human)
Description:
Q92905
Residue:
334
Sequence:
MAASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQINIS
  
Inhibitor
Name:
BDBM224012
Synonyms:
Capzimin | US10005735, Compound 12
Type:
Small organic molecule
Emp. Form.:
C15H13N3OS2
Mol. Mass.:
315.413
SMILES:
Sc1cccc2cc(cnc12)C(=O)NCCc1nccs1
Structure:
Search PDB for entries with ligand similarity: