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Target
Fibroblast growth factor receptor 2 [403-822]
Ligand
BDBM462139
Substrate
n/a
IC50
1.50±n/a nM
Citation
 Andrews, SW; Blake, JF; Cook, A; Gunawardana, IW; Hunt, KW; Metcalf, AT; Moreno, D; Ren, L; Tang, TP 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases US Patent  US10766881 Publication Date 9/8/2020 
Target
Name:
Fibroblast growth factor receptor 2 [403-822]
Synonyms:
BEK | FGFR2 | FGFR2_HUMAN | Fibroblast growth factor receptor 2 (FGFR2)(403-822) | KGFR | KSAM
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47577.40
Organism:
Homo sapiens (Human)
Description:
aa 403-822
Residue:
420
Sequence:
NTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
  
Inhibitor
Name:
BDBM462139
Synonyms:
US10766881, Example 60
Type:
Small organic molecule
Emp. Form.:
C28H31Cl2N7O4
Mol. Mass.:
600.496
SMILES:
COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(c1)-c1ccc(=O)n(n1)-c1c(Cl)c(OC)cc(OC)c1Cl |(-12.66,-2.5,;-11.57,-1.41,;-10.09,-1.8,;-9,-.72,;-7.51,-1.11,;-6.42,-.03,;-4.93,-.42,;-4.53,-1.91,;-5.62,-3,;-7.11,-2.6,;-3.05,-2.31,;-2.14,-1.06,;-.68,-1.54,;-.68,-3.08,;-2.14,-3.56,;.66,-.77,;.66,.77,;1.99,1.54,;3.33,.77,;4.66,1.54,;3.33,-.77,;1.99,-1.54,;4.66,-1.54,;4.66,-3.08,;5.99,-3.85,;7.33,-3.08,;8.66,-3.85,;7.33,-1.54,;5.99,-.77,;8.66,-.77,;9.99,-1.54,;9.99,-3.08,;11.33,-.77,;12.66,-1.54,;12.66,-3.08,;11.33,.77,;9.99,1.54,;9.99,3.08,;8.66,3.85,;8.66,.77,;7.33,1.54,)|
Structure:
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