Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 2 [403-822]
Ligand
BDBM350078
Substrate
n/a
IC50
6.20±n/a nM
Citation
 Andrews, SW; Blake, JF; Cook, A; Gunawardana, IW; Hunt, KW; Metcalf, AT; Moreno, D; Ren, L; Tang, TP 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases US Patent  US10766881 Publication Date 9/8/2020 
Target
Name:
Fibroblast growth factor receptor 2 [403-822]
Synonyms:
BEK | FGFR2 | FGFR2_HUMAN | Fibroblast growth factor receptor 2 (FGFR2)(403-822) | KGFR | KSAM
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47577.40
Organism:
Homo sapiens (Human)
Description:
aa 403-822
Residue:
420
Sequence:
NTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
  
Inhibitor
Name:
BDBM350078
Synonyms:
US10208024, Example 77 | US10766881, Example 77
Type:
Small organic molecule
Emp. Form.:
C23H22Cl2N8O3
Mol. Mass.:
529.379
SMILES:
COc1cc(OC)c(Cl)c(c1Cl)-n1nc(cc(C)c1=O)-c1nc(cnc1N)-c1cnn(c1)C1CNC1 |(10.38,,;9.05,-.77,;7.71,,;7.71,1.54,;6.38,2.31,;6.38,3.85,;7.71,4.62,;5.04,1.54,;3.71,2.31,;5.04,,;6.38,-.77,;6.38,-2.31,;3.71,-.77,;2.38,,;1.04,-.77,;1.04,-2.31,;2.38,-3.08,;2.38,-4.62,;3.71,-2.31,;5.04,-3.08,;-.29,,;-1.62,-.77,;-2.96,,;-2.96,1.54,;-1.62,2.31,;-.29,1.54,;1.04,2.31,;-4.29,-.77,;-4.29,-2.31,;-5.76,-2.79,;-6.66,-1.54,;-5.76,-.29,;-8.2,-1.54,;-9.29,-.45,;-10.38,-1.54,;-9.29,-2.63,)|
Structure:
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