Reaction Details
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Target
Gag-Pol polyprotein [1148-1435]
Ligand
BDBM28232
Substrate
[3H]Target DNA
Meas. Tech.
HIV Integrase Strand Transfer Scintillation Proximity Assay (SPA)
pH
7.2±n/a
Temperature
310.15±n/a K
IC50
130±n/a nM
Citation
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More Info.:
Target
Name:
Gag-Pol polyprotein [1148-1435]
Synonyms:
HIV-1 Integrase | POL_HV1H2 | gag-pol
Type:
Enzyme
Mol. Mass.:
32171.42
Organism:
Human immunodeficiency virus type 1
Description:
The sequence encoding the 288-amino-acid wild-type full-length integrase was cloned with an N-terminal 6His tag, and expressed in E. coli.
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTGATVRAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRNPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
Inhibitor
Name:
BDBM28232
Synonyms:
7-(5-benzyl-1,3,4-oxadiazol-2-yl)-1,6-naphthyridin-8-ol | oxadiazole substituted naphthyridine, 17a
Type:
Small organic molecule
Emp. Form.:
C17H12N4O2
Mol. Mass.:
304.3028
SMILES:
Oc1c(ncc2cccnc12)-c1nnc(Cc2ccccc2)o1
Substrate
Name:
[3H]Target DNA
Synonyms:
n/a
Type:
Duplex DNA
Mol. Mass.:
2689.01
Organism:
n/a
Description:
n/a
Residue:
34
Sequence:
AAAAAAATGACCAAGGGCTAATTCACTAAAAAAA