Reaction Details Report a problem with these data
Target
Neutrophil cytosol factor 1 [S99G]
Ligand
BDBM55549
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs)
IC50
50000±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs) PubChem Bioassay (2008)[AID] 
Target
Name:
Neutrophil cytosol factor 1 [S99G]
Synonyms:
NCF1 | NCF1_HUMAN | NOXO2 | SH3PXD1A | neutrophil cytosolic factor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44664.39
Organism:
Human
Description:
gi_115298672
Residue:
390
Sequence:
MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSKPQPAVPPRPSADLILNRCSESTKRKLASAV
  
Inhibitor
Name:
BDBM55549
Synonyms:
2-hydroxy-N-[(Z)-[1-[2-(3-methylanilino)-2-oxoethyl]-2-oxo-3-indolylidene]amino]benzamide | 2-hydroxy-N-[(Z)-[1-[2-(3-methylanilino)-2-oxoethyl]-2-oxoindol-3-ylidene]amino]benzamide | 2-hydroxy-N-[(Z)-[2-keto-1-[2-keto-2-(m-toluidino)ethyl]indolin-3-ylidene]amino]benzamide | 2-{3-[(2-Hydroxy-benzoyl)-hydrazono]-2-oxo-2,3-dihydro-indol-1-yl}-N-m-tolyl-acetamide | MLS000548432 | N-[(Z)-[1-[2-[(3-methylphenyl)amino]-2-oxidanylidene-ethyl]-2-oxidanylidene-indol-3-ylidene]amino]-2-oxidanyl-benzamide | SMR000171366 | cid_6870326
Type:
Small organic molecule
Emp. Form.:
C24H20N4O4
Mol. Mass.:
428.44
SMILES:
Cc1cccc(NC(=O)CN2C(=O)\C(=N/NC(=O)c3ccccc3O)c3ccccc23)c1
Structure:
Search PDB for entries with ligand similarity: