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Target
NAD-dependent protein deacetylase sirtuin-2
Ligand
BDBM50523791
Substrate
n/a
Meas. Tech.
ChEMBL_1891144 (CHEMBL4392971)
IC50
10200±n/a nM
Citation
 Ali, TFS; Ciftci, HI; Radwan, MO; Koga, R; Ohsugi, T; Okiyama, Y; Honma, T; Nakata, A; Ito, A; Yoshida, M; Fujita, M; Otsuka, M New SIRT2 inhibitors: Histidine-based bleomycin spin-off. Bioorg Med Chem 27:1767-1775 (2019) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-2
Synonyms:
NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2)
Type:
Hydrolase
Mol. Mass.:
43172.62
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
389
Sequence:
MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
  
Inhibitor
Name:
BDBM50523791
Synonyms:
CHEMBL4473932
Type:
Small organic molecule
Emp. Form.:
C32H29BrN4O2
Mol. Mass.:
581.502
SMILES:
COC(=O)[C@H](Cc1cn(cn1)C(c1ccccc1)(c1ccccc1)c1ccccc1)NCc1ccc(Br)cn1 |r|
Structure:
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