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Target
Substance-K receptor
Ligand
BDBM50110651
Substrate
n/a
Meas. Tech.
ChEBML_209196
Ki
8.5±n/a nM
Citation
 Reichard, GA; Spitler, J; Aslanian, R; Mutahi, M; Shih, NY; Lin, L; Ting, PC; Anthes, JC; Piwinski, JJ Structure-activity relationships of oxime neurokinin antagonists: oxime modifications. Bioorg Med Chem Lett 12:833-6 (2002) [PubMed]  Article 
Target
Name:
Substance-K receptor
Synonyms:
NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3
Type:
Protein
Mol. Mass.:
44455.78
Organism:
Homo sapiens (Human)
Description:
P21452
Residue:
398
Sequence:
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
  
Inhibitor
Name:
BDBM50110651
Synonyms:
3,5-Dichloro-N-[3-(3,4-dichloro-phenyl)-2-[(Z)-1H-imidazol-4-ylmethoxyimino]-5-(2-oxo-[1,4']bipiperidinyl-1'-yl)-pentyl]-N-methyl-benzamide | CHEMBL353027
Type:
Small organic molecule
Emp. Form.:
C33H38Cl4N6O3
Mol. Mass.:
708.505
SMILES:
CN(C\C(=N/OCc1cnc[nH]1)C(CCN1CCC(CC1)N1CCCCC1=O)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1
Structure:
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