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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50250186
Substrate
n/a
Meas. Tech.
ChEMBL_2081457 (CHEMBL4737248)
EC50
1900±n/a nM
Citation
 Ledneczki, I; Tapolcsányi, P; Gábor, E; Visegrády, A; Vass, M; Éles, J; Holm, P; Horváth, A; Pocsai, A; Mahó, S; Greiner, I; Krámos, B; Béni, Z; Kóti, J; Káncz, AE; Thán, M; Kolok, S; Laszy, J; Balázs, O; Bugovits, G; Nagy, J; Vastag, M; Szájli, Á; Bozó, É; Lévay, G; Lendvai, B; Némethy, Z Discovery of novel positive allosteric modulators of the ?7 nicotinic acetylcholine receptor: Scaffold hopping approach. Eur J Med Chem 214:0 (2021) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50250186
Synonyms:
4-(3-Acetyl-5-(4-chlorophenyl)-2-methyl-1H-pyrrol-1-yl)benzenesulfonamide | CHEMBL522440
Type:
Small organic molecule
Emp. Form.:
C19H17ClN2O3S
Mol. Mass.:
388.868
SMILES:
CC(=O)c1cc(-c2ccc(Cl)cc2)n(c1C)-c1ccc(cc1)S(N)(=O)=O
Structure:
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