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Target
Neutral ceramidase
Ligand
BDBM50569048
Substrate
n/a
Meas. Tech.
ChEMBL_2107504 (CHEMBL4816179)
Ki
3600±n/a nM
Citation
 Bielsa, N; Casasampere, M; Aseeri, M; Casas, J; Delgado, A; Abad, JL; Fabriās, G Discovery of deoxyceramide analogs as highly selective ACER3 inhibitors in live cells. Eur J Med Chem 216:0 (2021) [PubMed]  Article 
Target
Name:
Neutral ceramidase
Synonyms:
ASAH2 | ASAH2_HUMAN | Acylsphingosine deacylase 2 | BCDase | HNAC1 | LCDase | N-CDase | N-acylsphingosine amidohydrolase 2 | NCDase | Neutral ceramidase soluble form | Non-lysosomal ceramidase | hCD
Type:
PROTEIN
Mol. Mass.:
85523.37
Organism:
Homo sapiens (Human)
Description:
ChEMBL_947546
Residue:
780
Sequence:
MAKRTFSNLETFLIFLLVMMSAITVALLSLLFITSGTIENHKDLGGHFFSTTQSPPATQGSTAAQRSTATQHSTATQSSTATQTSPVPLTPESPLFQNFSGYHIGVGRADCTGQVADINLMGYGKSGQNAQGILTRLYSRAFIMAEPDGSNRTVFVSIDIGMVSQRLRLEVLNRLQSKYGSLYRRDNVILSGTHTHSGPAGYFQYTVFVIASEGFSNQTFQHMVTGILKSIDIAHTNMKPGKIFINKGNVDGVQINRSPYSYLQNPQSERARYSSNTDKEMIVLKMVDLNGDDLGLISWFAIHPVSMNNSNHLVNSDNVGYASYLLEQEKNKGYLPGQGPFVAAFASSNLGDVSPNILGPRCINTGESCDNANSTCPIGGPSMCIAKGPGQDMFDSTQIIGRAMYQRAKELYASASQEVTGPLASAHQWVDMTDVTVWLNSTHASKTCKPALGYSFAAGTIDGVGGLNFTQGKTEGDPFWDTIRDQILGKPSEEIKECHKPKPILLHTGELSKPHPWHPDIVDVQIITLGSLAITAIPGEFTTMSGRRLREAVQAEFASHGMQNMTVVISGLCNVYTHYITTYEEYQAQRYEAASTIYGPHTLSAYIQLFRNLAKAIATDTVANLSRGPEPPFFKQLIVPLIPSIVDRAPKGRTFGDVLQPAKPEYRVGEVAEVIFVGANPKNSVQNQTHQTFLTVEKYEATSTSWQIVCNDASWETRFYWHKGLLGLSNATVEWHIPDTAQPGIYRIRYFGHNRKQDILKPAVILSFEGTSPAFEVVTI
  
Inhibitor
Name:
BDBM50569048
Synonyms:
CHEMBL4861323
Type:
Small organic molecule
Emp. Form.:
C29H49NO5
Mol. Mass.:
491.7031
SMILES:
CCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](C)NC(=O)c1ccc(OCCCOCOC)cc1 |r|
Structure:
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