Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM50581496
Substrate
n/a
Meas. Tech.
ChEMBL_2151141 (CHEMBL5035603)
Ki
5.0±n/a nM
Citation
 Xiong, J; Zhuang, T; Ma, Y; Xu, J; Ye, J; Ma, R; Zhang, S; Liu, X; Liu, BF; Hao, C; Zhang, G; Chen, Y Optimization of bifunctional piperidinamide derivatives as ? Eur J Med Chem 226:0 (2021) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50581496
Synonyms:
CHEMBL5087044
Type:
Small organic molecule
Emp. Form.:
C24H32N2O2
Mol. Mass.:
380.5231
SMILES:
COCC(=O)N(CC(C)N1CCC(Cc2ccccc2)CC1)c1ccccc1
Structure:
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