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Target
Cathepsin K
Ligand
BDBM50179450
Substrate
n/a
Meas. Tech.
ChEMBL_341068 (CHEMBL866588)
IC50
16±n/a nM
Citation
Barrett, DG; Catalano, JG; Deaton, DN; Hassell, AM; Long, ST; Miller, AB; Miller, LR; Ray, JA; Samano, V; Shewchuk, LM; Wells-Knecht, KJ; Willard, DH; Wright, LL Novel, potent P2-P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors. Bioorg Med Chem Lett 16:1735-9 (2006) [PubMed] Article
More Info.:
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
Inhibitor
Name:
BDBM50179450
Synonyms:
(S)-4,4-dimethyl-1-(morpholine-4-carbonyl)-2-oxopyrrolidin-3-yl (S)-1,2-dioxo-1-((R)-1-phenylethylamino)heptan-3-ylcarbamate | CHEMBL206191
Type:
Small organic molecule
Emp. Form.:
C27H38N4O7
Mol. Mass.:
530.6132
SMILES:
CCCC[C@H](NC(=O)O[C@@H]1C(=O)N(CC1(C)C)C(=O)N1CCOCC1)C(=O)C(=O)N[C@H](C)c1ccccc1