Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 5
Ligand
BDBM50185141
Substrate
n/a
Meas. Tech.
ChEMBL_358034 (CHEMBL871183)
IC50
19.0±n/a nM
Citation
Colandrea, VJ; Legiec, IE; Huo, P; Yan, L; Hale, JJ; Mills, SG; Bergstrom, J; Card, D; Chebret, G; Hajdu, R; Keohane, CA; Milligan, JA; Rosenbach, MJ; Shei, GJ; Mandala, SM 2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists. Bioorg Med Chem Lett 16:2905-8 (2006) [PubMed] Article
More Info.:
Target
Name:
Sphingosine 1-phosphate receptor 5
Synonyms:
EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41796.42
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
398
Sequence:
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
Inhibitor
Name:
BDBM50185141
Synonyms:
(+/-)-2-(cis-5-(4-(5-(4-((R)-3,3-difluorocyclopentyl)phenyl)-1,2,4-oxadiazol-3-yl)phenyl)pyrrolidin-2-yl)acetic acid | 2-(cis-5-(4-(5-(4-((R)-3,3-difluorocyclopentyl)phenyl)-1,2,4-oxadiazol-3-yl)phenyl)pyrrolidin-2-yl)acetic acid | CHEMBL209076
Type:
Small organic molecule
Emp. Form.:
C25H25F2N3O3
Mol. Mass.:
453.4811
SMILES:
OC(=O)C[C@@H]1CC[C@@H](N1)c1ccc(cc1)-c1noc(n1)-c1ccc(cc1)[C@@H]1CCC(F)(F)C1