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Target
RAC-gamma serine/threonine-protein kinase
Ligand
BDBM50607142
Substrate
n/a
Meas. Tech.
ChEMBL_2262235 (CHEMBL5217246)
IC50
1800±n/a nM
Citation
 Yu, X; Xu, J; Cahuzac, KM; Xie, L; Shen, Y; Chen, X; Liu, J; Parsons, RE; Jin, J Novel Allosteric Inhibitor-Derived AKT Proteolysis Targeting Chimeras (PROTACs) Enable Potent and Selective AKT Degradation in KRAS/BRAF Mutant Cells. J Med Chem 65:14237-14260 (2022) [PubMed] 
Target
Name:
RAC-gamma serine/threonine-protein kinase
Synonyms:
AKT3 | AKT3_HUMAN | PKB gamma | PKBG | Protein kinase Akt-3 | Protein kinase B (Akt 3) | Protein kinase B, gamma | RAC-PK-gamma | RAC-gamma serine/threonine-protein kinase | STK-2 | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT3
Type:
Enzyme
Mol. Mass.:
55769.36
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
479
Sequence:
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
  
Inhibitor
Name:
BDBM50607142
Synonyms:
CHEMBL5220918
Type:
Small organic molecule
Emp. Form.:
C71H85N11O5S
Mol. Mass.:
1204.57
SMILES:
C[C@H](NC(=O)[C@H]1C[C@@H](CN1C(=O)[C@@H](NC(=O)CCCCCCCCCCNC(=O)CCc1cccc(c1)-c1ccc2nc(-c3cccnc3N)n(-c3ccc(cc3)C3(N)CCC3)c2n1)C(C)(C)C)OCc1ccccc1)c1ccc(cc1)-c1scnc1C |r|
Structure:
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