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Target
D(2) dopamine receptor
Ligand
BDBM50221363
Substrate
n/a
Meas. Tech.
ChEMBL_449578 (CHEMBL897619)
Ki
429±n/a nM
Citation
 Sasse, BC; Mach, UR; Leppaenen, J; Calmels, T; Stark, H Hybrid approach for the design of highly affine and selective dopamine D(3) receptor ligands using privileged scaffolds of biogenic amine GPCR ligands. Bioorg Med Chem 15:7258-73 (2007) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50221363
Synonyms:
CHEMBL239065 | N-[4-(2,3,4,5,10,15-hexahydro-1H-dibenzo[b:e]-pyrazino[2,1-g]azepin-1-yl)butyl]cinnamide
Type:
Small organic molecule
Emp. Form.:
C30H33N3O
Mol. Mass.:
451.6025
SMILES:
O=C(NCCCCN1CCN2C(C1)c1ccccc1Cc1ccccc21)\C=C\c1ccccc1 |w:11.11|
Structure:
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