Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50066615
Substrate
n/a
Meas. Tech.
ChEBML_69670
Ki
13000±n/a nM
Citation
 Quan, ML; Pruitt, JR; Ellis, CD; Liauw, AY; Galemmo, RA; Stouten, PF; Wityak, J; Knabb, RM; Thoolen, MJ; Wong, PC; Wexler, RR Bisbenzamidine isoxazoline derivatives as factor Xa inhibitors Bioorg Med Chem Lett 7:2813-2818 (1997)    Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50066615
Synonyms:
(E,Z)-2,7-Bis(4-amidinobenzylidine)cycloheptan-1-one | 2-[1-[4-amino(imino)methylphenyl]-(E)-methylidene]-7-[1-[4-amino(imino)methylphenyl]-(Z)-methylidene]-1-cycloheptanone | CHEMBL94336
Type:
Small organic molecule
Emp. Form.:
C23H24N4O
Mol. Mass.:
372.4629
SMILES:
NC(=N)c1ccc(\C=C2\CCCC\C(=C/c3ccc(cc3)C(N)=N)C2=O)cc1
Structure:
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