Reaction Details Report a problem with these data
Target
Aurora kinase B
Ligand
BDBM50310624
Substrate
n/a
Meas. Tech.
ChEMBL_620386 (CHEMBL1112281)
IC50
600±n/a nM
Citation
Zhong, M; Bui, M; Shen, W; Baskaran, S; Allen, DA; Elling, RA; Flanagan, WM; Fung, AD; Hanan, EJ; Harris, SO; Heumann, SA; Hoch, U; Ivy, SN; Jacobs, JW; Lam, S; Lee, H; McDowell, RS; Oslob, JD; Purkey, HE; Romanowski, MJ; Silverman, JA; Tangonan, BT; Taverna, P; Yang, W; Yoburn, JC; Yu, CH; Zimmerman, KM; O'Brien, T; Lew, W 2-Aminobenzimidazoles as potent Aurora kinase inhibitors. Bioorg Med Chem Lett 19:5158-61 (2009) [PubMed] Article
More Info.:
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Human
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
Inhibitor
Name:
BDBM50310624
Synonyms:
CHEMBL1081881 | N-(2-(6-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-ylamino)pyridin-3-yl)ethyl)thieno[3,2-d]pyrimidin-4-amine
Type:
Small organic molecule
Emp. Form.:
C21H16F3N7S
Mol. Mass.:
455.459
SMILES:
FC(F)(F)c1ccc2nc(Nc3ccc(CCNc4ncnc5ccsc45)cn3)[nH]c2c1