Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50022184
Substrate
n/a
Meas. Tech.
ChEBML_31926
IC50
10000±n/a nM
Citation
Brubaker, AN; DeRuiter, J; Whitmer, WL Synthesis and rat lens aldose reductase inhibitory activity of some benzopyran-2-ones. J Med Chem 29:1094-9 (1986) [PubMed] Article
More Info.:
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
Inhibitor
Name:
BDBM50022184
Synonyms:
7,8-Dihydroxy-4-methyl-2H-chromen-2-one (3) | 7,8-Dihydroxy-4-methyl-chromen-2-one | 7,8-dihydroxy-4-methyl-2H-chromen-2-one | 7,8-dihydroxy-4-methylcoumarin | CHEMBL276618
Type:
Small organic molecule
Emp. Form.:
C10H8O4
Mol. Mass.:
192.1681
SMILES:
Cc1cc(=O)oc2c(O)c(O)ccc12