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Target
Oxysterols receptor LXR-beta
Ligand
BDBM50306041
Substrate
n/a
Meas. Tech.
ChEMBL_605693 (CHEMBL1071223)
EC50
1660±n/a nM
Citation
 Singhaus, RR; Bernotas, RC; Steffan, R; Matelan, E; Quinet, E; Nambi, P; Feingold, I; Huselton, C; Wilhelmsson, A; Goos-Nilsson, A; Wrobel, J 3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists. Bioorg Med Chem Lett 20:521-5 (2010) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50306041
Synonyms:
8-chloro-2-isopropyl-3-(3-(3-(methylsulfonyl)phenoxy)phenyl)imidazo[1,2-a]pyridine | CHEMBL603956
Type:
Small organic molecule
Emp. Form.:
C23H21ClN2O3S
Mol. Mass.:
440.942
SMILES:
CC(C)c1nc2c(Cl)cccn2c1-c1cccc(Oc2cccc(c2)S(C)(=O)=O)c1
Structure:
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