Reaction Details Report a problem with these data
Target
Histidine-rich protein PFHRP-II
Ligand
BDBM50134470
Substrate
n/a
Meas. Tech.
ChEBML_155132
IC50
170000±n/a nM
Citation
 Ryckebusch, A; Deprez-Poulain, R; Debreu-Fontaine, MA; Vandaele, R; Mouray, E; Grellier, P; Sergheraert, C Synthesis and antimalarial evaluation of new 1,4-bis(3-aminopropyl)piperazine derivatives. Bioorg Med Chem Lett 13:3783-7 (2003) [PubMed]  Article 
Target
Name:
Histidine-rich protein PFHRP-II
Synonyms:
HRP1_PLAFA | Histidine-rich protein | Histidine-rich protein PFHRP-II
Type:
PROTEIN
Mol. Mass.:
35156.49
Organism:
Plasmodium falciparum
Description:
ChEMBL_500704
Residue:
332
Sequence:
MVSFSKNKVLSAAVFASVLLLDNNNSAFNNNLCSKNAKGLNLNKRLLHETQAHVDDAHHAHHVADAHHAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAAYAHHAHHASDAHHAADAHHAAYAHHAHHAADAHHAADAHHAAYAHHAHHAADAHHAADAHHATDAHHAHHAADAHHATDAHHAADAHHAADAHHATDAHHAADAHHATDAHHAADAHHAADAHHATDSHHAHHAADAHHAAAHHATDAHHAAAHHATDAHHAAAHHEAATHCLRH
  
Inhibitor
Name:
BDBM50134470
Synonyms:
CHEMBL125382 | Diisobutyl-(3-{4-[3-(4-methoxy-benzylamino)-propyl]-piperazin-1-yl}-propyl)-amine
Type:
Small organic molecule
Emp. Form.:
C26H48N4O
Mol. Mass.:
432.6855
SMILES:
COc1ccc(CNCCCN2CCN(CCCN(CC(C)C)CC(C)C)CC2)cc1
Structure:
Search PDB for entries with ligand similarity: