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Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM50423149
Substrate
n/a
Meas. Tech.
ChEMBL_446786 (CHEMBL897085)
IC50
63±n/a nM
Citation
 Hall, A; Atkinson, S; Brown, SH; Chessell, IP; Chowdhury, A; Giblin, GM; Goldsmith, P; Healy, MP; Jandu, KS; Johnson, MR; Michel, AD; Naylor, A; Sweeting, JA Discovery of novel, non-acidic 1,5-biaryl pyrrole EP1 receptor antagonists. Bioorg Med Chem Lett 17:1200-5 (2007) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
PE2R1_HUMAN | PGE receptor, EP1 subtype | PTGER1 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP1 subtype | Prostaglandin E2 receptor EP1 subtype (EP1) | Prostanoid EP1 receptor
Type:
Enzyme
Mol. Mass.:
41834.57
Organism:
Homo sapiens (Human)
Description:
P34995
Residue:
402
Sequence:
MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
  
Inhibitor
Name:
BDBM50423149
Synonyms:
CHEMBL393416
Type:
Small organic molecule
Emp. Form.:
C25H21ClN2O2
Mol. Mass.:
416.899
SMILES:
Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(c1)C(N)=O
Structure:
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