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Target
Thromboxane A2 receptor
Ligand
BDBM50434977
Substrate
n/a
Meas. Tech.
ChEMBL_961612 (CHEMBL2388929)
IC50
>25000±n/a nM
Citation
 Fretz, H; Valdenaire, A; Pothier, J; Hilpert, K; Gnerre, C; Peter, O; Leroy, X; Riederer, MA Identification of 2-(2-(1-naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic acid (setipiprant/ACT-129968), a potent, selective, and orally bioavailable chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonist. J Med Chem 56:4899-911 (2013) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50434977
Synonyms:
CHEMBL2385905
Type:
Small organic molecule
Emp. Form.:
C28H25ClN2O3
Mol. Mass.:
472.963
SMILES:
CCc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCc2c(C1)c1cccc(Cl)c1n2CC(O)=O
Structure:
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