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Target
Dual specificity protein phosphatase 3
Ligand
BDBM50012285
Substrate
n/a
Meas. Tech.
ChEMBL_1351244 (CHEMBL3271699)
IC50
18300±n/a nM
Citation
 Thuaud, F; Kojima, S; Hirai, G; Oonuma, K; Tsuchiya, A; Uchida, T; Tsuchimoto, T; Sodeoka, M RE12 derivatives displaying Vaccinia H1-related phosphatase (VHR) inhibition in the presence of detergent and their anti-proliferative activity against HeLa cells. Bioorg Med Chem 22:2771-82 (2014) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM50012285
Synonyms:
CHEMBL3260371
Type:
Small organic molecule
Emp. Form.:
C31H32ClNO5
Mol. Mass.:
534.042
SMILES:
Cc1cccc(CN\C(CCCCc2cccc(OCc3cccc(Cl)c3)c2)=C2/C(=O)OC(CO)C2=O)c1
Structure:
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