Reaction Details Report a problem with these data
Target
Growth factor receptor-bound protein 2
Ligand
BDBM5104
Substrate
Grb2 SH2 Binding Substrate
Meas. Tech.
Competitive Binding Assay
IC50
>500000±n/a nM
Citation
 Vu, CB; Corpuz, EG; Merry, TJ; Pradeepan, SG; Bartlett, C; Bohacek, RS; Botfield, MC; Eyermann, CJ; Lynch, BA; MacNeil, IA; Ram, MK; van Schravendijk, MR; Violette, S; Sawyer, TK Discovery of potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70. J Med Chem 42:4088-98 (1999) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM5104
Synonyms:
1,2,4-Oxadiazole Analogue 15a | 4-[(2S)-2-{[(1S)-2-hydroxy-1-(3-{[4-(trifluoromethyl)phenyl]methyl}-1,2,4-oxadiazol-5-yl)ethyl]carbamoyl}-2-(1-phenylacetamido)ethyl]phenoxyphosphonic acid
Type:
Small organic molecule
Emp. Form.:
C29H28F3N4O8P
Mol. Mass.:
648.5236
SMILES:
OC[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)Cc1ccccc1)c1nc(Cc2ccc(cc2)C(F)(F)F)no1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Grb2 SH2 Binding Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1316.99
Organism:
n/a
Description:
n/a
Residue:
11
Sequence:
FLRGPYVNVNH