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Target
S-adenosylmethionine synthase isoform type-2
Ligand
BDBM508044
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
<200±n/a nM
Citation
 Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors US Patent  US11084798 Publication Date 8/10/2021 
Target
Name:
S-adenosylmethionine synthase isoform type-2
Synonyms:
AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II
Type:
Protein
Mol. Mass.:
43659.65
Organism:
Human
Description:
P31153
Residue:
395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
  
Inhibitor
Name:
BDBM508044
Synonyms:
3-((1-(2-chlorophenyl)-2-oxo-7- (trifluoro-methyl)-1,2-dihydropyrido- [2,3-d]pyrimidin-4-yl)amino)- propanenitrile | US11046691, Compound 278 | US11084798, Cpd No 278 | US11130759, Cpd. No. 278
Type:
Small organic molecule
Emp. Form.:
C17H11ClF3N5O
Mol. Mass.:
393.75
SMILES:
FC(F)(F)c1ccc2c(NCCC#N)nc(=O)n(-c3ccccc3Cl)c2n1 |(-5.68,-1.91,;-4.28,-2.56,;-4.15,-4.09,;-5.54,-3.44,;-3.02,-1.67,;-3.15,-.14,;-1.89,.74,;-.5,.09,;.76,.98,;.63,2.51,;1.89,3.39,;1.76,4.93,;3.02,5.81,;4.28,6.69,;2.16,.33,;2.29,-1.21,;3.69,-1.86,;1.03,-2.09,;1.17,-3.63,;-.09,-4.51,;.04,-6.04,;1.44,-6.69,;2.7,-5.81,;2.56,-4.28,;3.82,-3.39,;-.36,-1.44,;-1.62,-2.32,)|
Structure:
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