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Target
S-adenosylmethionine synthase isoform type-2
Ligand
BDBM508404
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
<200±n/a nM
Citation
 Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors US Patent  US11084798 Publication Date 8/10/2021 
Target
Name:
S-adenosylmethionine synthase isoform type-2
Synonyms:
AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II
Type:
Protein
Mol. Mass.:
43659.65
Organism:
Human
Description:
P31153
Residue:
395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
  
Inhibitor
Name:
BDBM508404
Synonyms:
4-amino-1-(3-chloropyridin-2-yl)-7- cyclopropylquinazolin-2(1H)-one | US11046691, Compound 715 | US11084798, Cpd No 715 | US11130759, Cpd. No. 715
Type:
Small organic molecule
Emp. Form.:
C16H13ClN4O
Mol. Mass.:
312.754
SMILES:
Nc1nc(=O)n(-c2ncccc2Cl)c2cc(ccc12)C1CC1 |(-4.1,.87,;-2.77,.1,;-2.77,-1.44,;-1.44,-2.21,;-1.44,-3.75,;-.1,-1.44,;1.23,-2.21,;2.56,-1.44,;3.9,-2.21,;3.9,-3.75,;2.56,-4.52,;1.23,-3.75,;-.1,-4.52,;-.1,.1,;1.23,.87,;1.23,2.41,;-.1,3.18,;-1.44,2.41,;-1.44,.87,;2.56,3.18,;4.1,3.18,;3.33,4.52,)|
Structure:
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