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Target
S-adenosylmethionine synthase isoform type-2
Ligand
BDBM508422
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
<200±n/a nM
Citation
 Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors US Patent  US11084798 Publication Date 8/10/2021 
Target
Name:
S-adenosylmethionine synthase isoform type-2
Synonyms:
AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II
Type:
Protein
Mol. Mass.:
43659.65
Organism:
Human
Description:
P31153
Residue:
395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
  
Inhibitor
Name:
BDBM508422
Synonyms:
1-(2-chlorophenyl)-7-cyclopropyl-4- (((1S,2S)-2-fluorocyclopropyl)amino)- quinazolin-2(1H)-one, single unknown enantiomer/atropisomer | US11046691, Compound 733 | US11046691, Compound 734 | US11084798, Cpd No 734 | US11130759, Cpd. No. 734
Type:
Small organic molecule
Emp. Form.:
C20H17ClFN3O
Mol. Mass.:
369.82
SMILES:
F[C@H]1C[C@@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |r,wU:1.0,wD:3.4,(-5.54,3.57,;-4.21,4.34,;-3.44,5.67,;-2.67,4.34,;-1.33,3.57,;-1.33,2.03,;-2.67,1.26,;-2.67,-.28,;-4,-1.05,;-1.33,-1.05,;-1.33,-2.59,;,-3.36,;,-4.9,;-1.33,-5.67,;-2.67,-4.9,;-2.67,-3.36,;-4,-2.59,;,-.28,;1.33,-1.05,;2.67,-.28,;2.67,1.26,;1.33,2.03,;,1.26,;4,-1.05,;4.77,-2.39,;5.54,-1.05,)|
Structure:
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