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Target
Tyrosine-protein kinase JAK1 [861-1152]
Ligand
BDBM173933
Substrate
n/a
Meas. Tech.
JAK1 Kinase Assay
IC50
141±n/a nM
Citation
 Brasca, MG; Bindi, S; Caldarelli, M; Nesi, M; Orrenius, SC; Panzeri, A Substituted pyrroles active as kinases inhibitors US Patent  US9688661 Publication Date 6/27/2017 
Target
Name:
Tyrosine-protein kinase JAK1 [861-1152]
Synonyms:
JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 (JAK1)
Type:
Protein
Mol. Mass.:
33439.94
Organism:
Homo sapiens (Human)
Description:
Human JAK1 variant (861-1152 aa)
Residue:
292
Sequence:
PATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
  
Inhibitor
Name:
BDBM173933
Synonyms:
US9688661, 5-(6-Aminopyrimidin-4-yl)-2-(5-chloro-2-ethylphenyl)-1H-pyrrole-3-carbonitrile (compd 9)
Type:
Small organic molecule
Emp. Form.:
C17H13ClN5
Mol. Mass.:
322.772
SMILES:
CCc1ccc(Cl)cc1-c1nc(cc1C#N)-c1cc(N)ncn1
Structure:
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