Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM303284
Substrate
n/a
Meas. Tech.
A2a Ki assay
Ki
0.500±n/a nM
Citation
 Ali, A; Kuang, R; Lim, Y; Lo, MM; Ting, PC; Biju, P; de Lera Ruiz, M; Degrado, SJ; Tung, AL; Henderson, TJ; Hong, L; Kim, J; Kim, DW; Lee, J; Wu, J; Wu, H; Xiao, Y; Yu, T; Zhou, G; Zhu, X; McCormick, KD; Tagat, JR; Xiao, D; Khan, T; Cao, J; Berlin, M; Zhang, Y Aminoquinazoline compounds as A2A antagonist US Patent  US10138212 Publication Date 11/27/2018 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM303284
Synonyms:
2-amino-N-[[6- (cyclopentylmethoxy- methyl)-2-pyridyl]methyl]-8- methoxy-quinazoline-4- carboxamide | US10138212, Example 49
Type:
Small organic molecule
Emp. Form.:
C23H27N5O3
Mol. Mass.:
421.4922
SMILES:
COc1cccc2c(nc(N)nc12)C(=O)NCc1cccc(COCC2CCCC2)n1 |$;;;;;;;;;;;;;;;HN;;;;;;;;;;;;;;;$|
Structure:
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