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Target
S-adenosylmethionine synthase isoform type-2
Ligand
BDBM507790
Substrate
n/a
Meas. Tech.
Phosphate Sensor Fluorescence Assay
IC50
<200±n/a nM
Citation
 Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors US Patent  US11130759 Publication Date 9/28/2021 
Target
Name:
S-adenosylmethionine synthase isoform type-2
Synonyms:
AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II
Type:
Protein
Mol. Mass.:
43659.65
Organism:
Human
Description:
P31153
Residue:
395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
  
Inhibitor
Name:
BDBM507790
Synonyms:
4-[((2S,1R)-2- fluorocyclopropyl)amino]-1-(2- chlorophenyl)-7-cyclopropyl- hydroquinazolin-2-one | US11046691, Compound 413 | US11084798, Cpd No 413 | US11130759, Cpd. No. 413
Type:
Small organic molecule
Emp. Form.:
C20H17ClFN3O
Mol. Mass.:
369.82
SMILES:
F[C@H]1C[C@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1 |r,wD:3.4,1.0,(5.54,3.57,;4.21,4.34,;3.44,5.67,;2.67,4.34,;1.33,3.57,;1.33,2.03,;2.67,1.26,;2.67,-.28,;4,-1.05,;1.33,-1.05,;1.33,-2.59,;2.67,-3.36,;2.67,-4.9,;1.33,-5.67,;,-4.9,;,-3.36,;-1.33,-2.59,;,-.28,;-1.33,-1.05,;-2.67,-.28,;-2.67,1.26,;-1.33,2.03,;,1.26,;-4,-1.05,;-5.54,-1.05,;-4.77,-2.39,)|
Structure:
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