Reaction Details Report a problem with these data
Target
Receptor-interacting serine/threonine-protein kinase 2
Ligand
BDBM303432
Substrate
n/a
Meas. Tech.
V9103X ADP-Glo Kinase Assay Custom
IC50
1.10±n/a nM
Citation
Cui, J; Gao, DA; Liu, P; McKibben, BP; Miller, CA; Razavi, H; Spencer, E; Ruppel, S; Padyana, AK Substituted benzamides as RIPK2 inhibitors US Patent US10138222 Publication Date 11/27/2018
More Info.:
Target
Name:
Receptor-interacting serine/threonine-protein kinase 2
Synonyms:
CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2
Type:
Protein
Mol. Mass.:
61201.30
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
540
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
Inhibitor
Name:
BDBM303432
Synonyms:
US10138222, Example 160
Type:
Small organic molecule
Emp. Form.:
C31H40N6O2
Mol. Mass.:
528.6883
SMILES:
COC1CCC(CC1)N1CCC(CC1)Nc1cncc(c1)-n1cc(cn1)-c1cc(ccc1C)C(=O)NC1CC1 |(-4.57,-12.55,;-5.66,-11.46,;-5.26,-9.97,;-6.35,-8.88,;-5.95,-7.39,;-4.46,-7,;-3.37,-8.09,;-3.77,-9.57,;-4.06,-5.51,;-5.15,-4.42,;-4.75,-2.93,;-3.27,-2.53,;-2.18,-3.62,;-2.58,-5.11,;-2.87,-1.05,;-1.38,-.65,;-.29,-1.74,;1.2,-1.34,;1.59,.15,;.51,1.24,;-.98,.84,;.9,2.73,;-0,3.97,;.9,5.22,;2.37,4.74,;2.37,3.2,;.51,6.7,;1.59,7.79,;1.2,9.28,;-.29,9.68,;-1.38,8.59,;-.98,7.1,;-2.07,6.01,;2.28,10.37,;1.89,11.86,;3.77,9.97,;4.86,11.06,;6.35,11.46,;5.26,12.55,)|