Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM524546
Substrate
n/a
Meas. Tech.
HTRF Assay
Ki
<10±n/a nM
Citation
 Wang, X; Han, H; McCammant, MS; Wu, L; Yao, W; Yu, Z; Zhao, L Fused pyrimidine derivatives as A2A / A2B inhibitors US Patent  US11168089 Publication Date 11/9/2021 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM524546
Synonyms:
US11168089, Ex. No. 22 | US11873304, Example 22
Type:
Small organic molecule
Emp. Form.:
C24H20F2N8O
Mol. Mass.:
474.4654
SMILES:
Nc1nc(cc2nc(Cc3c(F)cccc3CN[C@H]3CCNC3=O)nn12)-c1cccc(C#N)c1F |r|
Structure:
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