Reaction Details Report a problem with these data
Target
Low molecular weight phosphotyrosine protein phosphatase
Ligand
BDBM533305
Substrate
n/a
Meas. Tech.
LMPTP Primary Screening Protocol
IC50
500±n/a nM
Citation
 Bottini, N; Zou, J; Ganji, SR; Stanford, S; Pinkerton, A; Chung, TD; Hedrick, M; Ardecky, R Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof US Patent  US11220486 Publication Date 1/11/2022 
Target
Name:
Low molecular weight phosphotyrosine protein phosphatase
Synonyms:
3.1.3.2 | 3.1.3.48 | ACP1 | Adipocyte acid phosphatase | LMW-PTP | LMW-PTPase | LMWPTP | Low molecular weight cytosolic acid phosphatase | PPAC_HUMAN | Red cell acid phosphatase 1 | low molecular weight phosphotyrosine protein phosphatase isoform c
Type:
n/a
Mol. Mass.:
18042.81
Organism:
Homo sapiens (Human)
Description:
P24666
Residue:
158
Sequence:
MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
  
Inhibitor
Name:
BDBM533305
Synonyms:
4-[(4-{4-[(3-piperidylpropyl)amino]-2- quinolyl}phenyl)sulfonyl]-1,4-thiazaperhydroine | US10626094, Example I235 | US11220486, Compound I235
Type:
Small organic molecule
Emp. Form.:
C27H34N4O2S2
Mol. Mass.:
510.714
SMILES:
O=S(=O)(N1CCSCC1)c1ccc(cc1)-c1cc(NCCCC2CCCNC2)c2ccccc2n1
Structure:
Search PDB for entries with ligand similarity: