Target
Non-receptor tyrosine-protein kinase TYK2 [556-888]
Ligand
BDBM399695
Substrate
n/a
Meas. Tech.
TYK2 JH2 Domain Binding Assay
Kd
0.3±n/a nM
Citation
 Greenwood, JRHarriman, GCLeit De Moradei, SMMasse, CEMcLean, THMondal, S TYK2 inhibitors and uses thereof US Patent  US11220508 Publication Date 1/11/2022 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [556-888]
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 (G556-D888) | Non-receptor tyrosine-protein kinase TYK2 (aa 556-888) | TYK2 | TYK2 JH2 Domain (aa 556-888) | TYK2_HUMAN
Type:
Protein
Mol. Mass.:
36941.98
Organism:
Homo sapiens (Human)
Description:
P29597 (aa 556-888)
Residue:
333
Sequence:
GETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASD
  
Inhibitor
Name:
BDBM399695
Synonyms:
US10323036, Compound I-139 | US10793574, Compound I-139 | US11220508, Compound I-139
Type:
Small organic molecule
Emp. Form.:
C20H17N7O3S
Mol. Mass.:
435.459
SMILES:
Cn1[nH]c2nc(Nc3ccc(cn3)C#N)cc(Nc3ccccc3S(C)(=O)=O)c2c1=O
Structure:
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